Photophysical and photochemical properties of &#945;-(8-quinolinoxy) zinc phthalocyanine for photodynamic therapy

Yuehui Lv; Songlin Yu; Huiyun Lin; Buhong Li; Jinping Xue; Shusen Xie

doi:10.1117/12.808446

18 February 2009 Photophysical and photochemical properties of α-(8-quinolinoxy) zinc phthalocyanine for photodynamic therapy

Yuehui Lv, Songlin Yu, Huiyun Lin, Buhong Li, Jinping Xue, Shusen Xie

Author Affiliations +

Proceedings Volume 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII; 71640W (2009) https://doi.org/10.1117/12.808446
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

The photophysical and photochemical properties of a newly developed photosensitizer α-(8-quinolinoxy) zinc phthalocyanine (α-(8-QLO)PcZn) were investigated for application in photodynamic therapy (PDT). The maximal Q band for α-(8-QLO)PcZn in dimethylformamide around 675 nm with the molar extinction coefficient of about 1.89×10⁵ mol^-1cm^-1. The fluorescence quantum and singlet oxygen (¹O₂) yields were determined to be 0.18±0.02 and 0.62±0.03, respectively. α-(8-QLO) PcZn has a diffuse cytoplasmic distribution in nasopharyngeal carcinoma C666-1 cells, and the efficient photodynamic cytotoxicity was observed. Our findings of this study suggest that α-(8-QLO)PcZn is a promising second-generation photosensitizer for PDT.

Citation Download Citation

Yuehui Lv, Songlin Yu, Huiyun Lin, Buhong Li, Jinping Xue, and Shusen Xie "Photophysical and photochemical properties of α-(8-quinolinoxy) zinc phthalocyanine for photodynamic therapy", Proc. SPIE 7164, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVIII, 71640W (18 February 2009); https://doi.org/10.1117/12.808446

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