Antibody immobilization within glass microstructured fibers: a route to sensitive and selective biosensors

T. M. Monro; Y. Ruan; H. Ebendorff-Heidepriem; H. Foo; P. Hoffmann; R. C. Moore

doi:10.1117/12.801887

16 May 2008 Antibody immobilization within glass microstructured fibers: a route to sensitive and selective biosensors

T. M. Monro, Y. Ruan, H. Ebendorff-Heidepriem, H. Foo, P. Hoffmann, R. C. Moore

Proceedings Volume 7004, 19th International Conference on Optical Fibre Sensors; 70046Q (2008) https://doi.org/10.1117/12.801887
Event: 19th International Conference on Optical Fibre Sensors, 2008, Perth, WA, Australia

Abstract

Glass microstructured optical fibers have been rendered biologically active for the first time active via the immobilization of antibodies within the holes in the fiber cross-section. This has been done by introducing coating layers to the internal surfaces of soft glass fibers. The detection of proteins that bind to these antibodies has been demonstrated experimentally within this system via the use of fluorescence labeling. The approach combines the sensitivity resulting from the long interaction lengths of filled fibers with the selectivity provided by the use of antibodies.

Citation Download Citation

T. M. Monro, Y. Ruan, H. Ebendorff-Heidepriem, H. Foo, P. Hoffmann, and R. C. Moore "Antibody immobilization within glass microstructured fibers: a route to sensitive and selective biosensors", Proc. SPIE 7004, 19th International Conference on Optical Fibre Sensors, 70046Q (16 May 2008); https://doi.org/10.1117/12.801887

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