Utility of point of care test devices for infectious disease testing of blood and oral fluid and application to rapid testing in the field

Stephen R. Lee; Keith W. Kardos; Graham D. Yearwood; Geraldine B. Guillon; Lisa A. Kurtz; Vijaya K. Mokkapati

doi:10.1117/12.783938

15 April 2008 Utility of point of care test devices for infectious disease testing of blood and oral fluid and application to rapid testing in the field

Stephen R. Lee, Keith W. Kardos, Graham D. Yearwood, Geraldine B. Guillon, Lisa A. Kurtz, Vijaya K. Mokkapati

Author Affiliations +

Proceedings Volume 6945, Optics and Photonics in Global Homeland Security IV; 69450D (2008) https://doi.org/10.1117/12.783938
Event: SPIE Defense and Security Symposium, 2008, Orlando, Florida, United States

Abstract

Rapid, point of care (POC) testing has been increasingly deployed as an aid in the diagnosis of infectious disease, due to its ability to deliver rapid, actionable results. In the case of HIV, a number of rapid test devices have been FDA approved and CLIA-waived in order to enable diagnosis of HIV infection outside of traditional laboratory settings. These settings include STD clinics, community outreach centers and mobile testing units, as well as identifying HIV infection among pregnant women and managing occupational exposure to infection. The OraQuick^® rapid test platform has been widely used to identify HIV in POC settings, due to its simplicity, ease of use and the ability to utilize oral fluid as an alternative specimen to blood. More recently, a rapid test for antibodies to hepatitis C virus (HCV) has been developed on the same test platform which uses serum, plasma, finger-stick blood, venous blood and oral fluid. Clinical testing using this POC test device has shown that performance is equivalent to state of the art, laboratory based tests. These devices may be suitable for rapid field testing of blood and other body fluids for the presence of infectious agents.

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Stephen R. Lee, Keith W. Kardos, Graham D. Yearwood, Geraldine B. Guillon, Lisa A. Kurtz, and Vijaya K. Mokkapati "Utility of point of care test devices for infectious disease testing of blood and oral fluid and application to rapid testing in the field", Proc. SPIE 6945, Optics and Photonics in Global Homeland Security IV, 69450D (15 April 2008); https://doi.org/10.1117/12.783938

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