Intramyocardial capillary blood volume estimated by whole-body CT: validation by micro-CT

Yue Dong M.D.; Patricia E. Beighley; Diane R Eaker; Mair Zamir; Erik L. Ritman M.D.

doi:10.1117/12.772713

12 March 2008 Intramyocardial capillary blood volume estimated by whole-body CT: validation by micro-CT

Yue Dong M.D., Patricia E. Beighley, Diane R Eaker, Mair Zamir, Erik L. Ritman M.D.

Proceedings Volume 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images; 691624 (2008) https://doi.org/10.1117/12.772713
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

Fast CT has shown that myocardial perfusion (F) is related to myocardial intramuscular blood volume (Bv) as Bv=A*F+B*F^1/2 where A,B are constant coefficients. The goal of this study was to estimate the range of diameters of the vessels that are represented by the A*F term. Pigs were placed in an Electron Beam CT (EBCT) scanner for a perfusion CT scan sequence over 40 seconds after an IV contrast agent injection. Intramyocardial blood volume (Bv) and flow (F) were calculated in a region of the myocardium perfused by the LAD. Coefficients A and B were estimated over the range of F=1-5ml/g/min. After the CT scan, the LAD was injected with Microfil^(R) contrast agent following which the myocardium was scanned by micro-CT at 20μm, 4μm and 2.5 μm cubic voxel resolutions. The Bv of the intramyocardial vessels was calculated for diameter ranges d=0-5, 5-10, 10-15, 15-20μm, etc. EBCT-derived data were presented so that it could be directly compared the micro-CT data. The results indicated that the blood in vessels less than 10μm in lumen diameter occupied 0.27-0.42 of total intravascular blood volume, which is in good agreement with EBCT-based values 0.28-0.48 (R² =0.96). We conclude that whole-body CT image data obtained during the passage of a bolus of IV contrast agent can provide a measure of the intramyocardial intracapillary blood volume.

Citation Download Citation

Yue Dong M.D., Patricia E. Beighley, Diane R Eaker, Mair Zamir, and Erik L. Ritman M.D. "Intramyocardial capillary blood volume estimated by whole-body CT: validation by micro-CT", Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 691624 (12 March 2008); https://doi.org/10.1117/12.772713

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KEYWORDS

Blood

Computed tomography

Capillaries

Arteries

Heart

Image resolution

Image segmentation

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