Hyperpolarized helium-3 magnetic resonance imaging of asthma: short-term reproducibility

Andrew Wheatley; Shayna McKay; Lindsay Mathew; Giles Santyr; David G. McCormack M.D.; Grace Parraga

doi:10.1117/12.771138

12 March 2008 Hyperpolarized helium-3 magnetic resonance imaging of asthma: short-term reproducibility

Andrew Wheatley, Shayna McKay, Lindsay Mathew, Giles Santyr, David G. McCormack M.D., Grace Parraga

Proceedings Volume 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images; 69161X (2008) https://doi.org/10.1117/12.771138
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

We examined subjects with exercise-induced asthma to assess the short-term reproducibility of hyperpolarized (Hp) helium-3 (³He) magnetic resonance imaging (MRI) of regional ventilation defects before asthma exacerbation. Our objective was to evaluate pre-exercise interscan Hp ³He MRI measurement reproducibility of subjects scanned on three separate occasions (5 ± 2 days between sessions). Magnetic resonance imaging was performed at 3.0 Tesla with a custom-built rigid elliptical ³He chest coil. Images for six subjects were evaluated by two observers; one who quantified ventilation defect score and ventilation defect volume and another who quantified percent ventilated volume. For all six subjects, pre-exercise ventilation defect location and number of defects were similar at all three visits suggesting persistence of many defects, but changes in defect volume and percent ventilated volume were detected.

Citation Download Citation

Andrew Wheatley, Shayna McKay, Lindsay Mathew, Giles Santyr, David G. McCormack M.D., and Grace Parraga "Hyperpolarized helium-3 magnetic resonance imaging of asthma: short-term reproducibility", Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 69161X (12 March 2008); https://doi.org/10.1117/12.771138

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