Hip fracture risk estimation based on bone mineral density of a biomechanically guided region of interest: a preliminary study

Wenjun Li; John Kornak; Caixia Li; Alain Koyama; Isra Saeed; Ying Lu; Thomas Lang

doi:10.1117/12.769588

3 April 2008 Hip fracture risk estimation based on bone mineral density of a biomechanically guided region of interest: a preliminary study

Wenjun Li, John Kornak, Caixia Li, Alain Koyama, Isra Saeed, Ying Lu, Thomas Lang

Author Affiliations +

Proceedings Volume 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images; 691616 (2008) https://doi.org/10.1117/12.769588
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

We aim to define a biomechanically-guided region of interest inside the proximal femur for improving fracture risk prediction based on bone density measurements. The central hypothesis is that by identifying and focusing on the proximal femoral tissues strongly associated with hip fracture risk, we can provide a better densitometric evaluation of fracture risk compared to current evaluations based on anatomically defined regions of interest using DXA or CT. To achieve this, we have constructed a hip statistical atlas of quantitative computed tomography (QCT) images by applying rigid and non-rigid inter-subject image registration to transform hip QCT scans of 15 fractured patients and 15 controls into a common reference space, and performed voxel-by-voxel t-tests between the two groups to identify bone tissues that showed the strongest relevance to hip fracture. Based on identification of this fracture-relevant tissue volume, we have generated a biomechanically-guided region of interest (B-ROI). We have applied BMD measured from this new region of interest to discriminate the fractured patients and controls, and compared it to BMD measured in the total proximal femur. For the femur ROI approach, the BMD values of the fractured patients and the controls had an overlap of 60 mg/cm³, and only 1 out of 15 fractured patients had BMD below the overlap region; for the B-ROI approach, a much narrower BMD overlap region of 28 mg/cm³ was observed, and 11 out of 15 fractured patients had BMDs below the overlap region.

Citation Download Citation

Wenjun Li, John Kornak, Caixia Li, Alain Koyama, Isra Saeed, Ying Lu, and Thomas Lang "Hip fracture risk estimation based on bone mineral density of a biomechanically guided region of interest: a preliminary study", Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 691616 (3 April 2008); https://doi.org/10.1117/12.769588

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Bone

Control systems

Image registration

Minerals

Tissues

Computed tomography

Neck

Show All Keywords

Keywords/Phrases

Search In:

Publication Years