Dynamic fMRI of a decision-making task

Manbir Singh; Witaya Sungkarat M.D.

doi:10.1117/12.770760

4 March 2008 Dynamic fMRI of a decision-making task

Manbir Singh, Witaya Sungkarat M.D.

Proceedings Volume 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images; 691608 (2008) https://doi.org/10.1117/12.770760
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

A novel fMRI technique has been developed to capture the dynamics of the evolution of brain activity during complex tasks such as those designed to evaluate the neural basis of decision-making under different situations. A task called the Iowa Gambling Task was used as an example. Six normal human volunteers were studied. The task was presented inside a 3T MRI and a dynamic fMRI study of the approximately 2s period between the beginning and end of the decision-making period was conducted by employing a series of reference functions, separated by 200 ms, designed to capture activation at different time-points within this period. As decision-making culminates with a button-press, the timing of the button press was chosen as the reference (t=0) and corresponding reference functions were shifted backward in steps of 200ms from this point up to the time when motor activity from the previous button press became predominant. SPM was used to realign, high-pass filter (cutoff 200s), normalize to the Montreal Neurological Institute (MNI) Template using a 12 parameter affine/non-linear transformation, 8mm Gaussian smoothing, and event-related General Linear Model analysis for each of the shifted reference functions. The t-score of each activated voxel was then examined to find its peaking time. A random effect analysis (p<0.05) showed prefrontal, parietal and bi-lateral hippocampal activation peaking at different times during the decision making period in the n=6 group study.

Citation Download Citation

Manbir Singh and Witaya Sungkarat M.D. "Dynamic fMRI of a decision-making task", Proc. SPIE 6916, Medical Imaging 2008: Physiology, Function, and Structure from Medical Images, 691608 (4 March 2008); https://doi.org/10.1117/12.770760

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