Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography

Yakov Nesterets; Tim Gureyev; Andrew Stevenson; Andrew Pogany; Steve Wilkins; Russell Kincaid; Hongwei Ye; Levon Vogelsang; Edward Lipson; Ioana Coman; Sylvain Fourmaux; Jean-Claude Kieffer; Andrzej Krol

doi:10.1117/12.772761

25 March 2008 Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography

Yakov Nesterets, Tim Gureyev, Andrew Stevenson, Andrew Pogany, Steve Wilkins, Russell Kincaid, Hongwei Ye, Levon Vogelsang, Edward Lipson, Ioana Coman, Sylvain Fourmaux, Jean-Claude Kieffer, Andrzej Krol

Author Affiliations +

Proceedings Volume 6913, Medical Imaging 2008: Physics of Medical Imaging; 69133Z (2008) https://doi.org/10.1117/12.772761
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 μm) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.

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Yakov Nesterets, Tim Gureyev, Andrew Stevenson, Andrew Pogany, Steve Wilkins, Russell Kincaid, Hongwei Ye, Levon Vogelsang, Edward Lipson, Ioana Coman, Sylvain Fourmaux, Jean-Claude Kieffer, and Andrzej Krol "Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography", Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 69133Z (25 March 2008); https://doi.org/10.1117/12.772761

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