Therapeutic targeting of tumors with imageable GFP-expressing Salmonella typhimurium auxotrophic mutants

Robert M. Hoffman; Katsuhiro Hayashi; Ming Zhao

doi:10.1117/12.772067

13 February 2008 Therapeutic targeting of tumors with imageable GFP-expressing Salmonella typhimurium auxotrophic mutants

Robert M. Hoffman, Katsuhiro Hayashi, Ming Zhao

Author Affiliations +

Proceedings Volume 6868, Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes; 68680K (2008) https://doi.org/10.1117/12.772067
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Tumor targeting Salmonella typhimurium has been developed. These bacteria were mutagenized and a strain auxotrophic for leucine and arguine was selected. This strain was also engineered to express GFP. This train, termed A1, could target prostate tumors in nude mouse models and inhibit their growth. A1 was passaged through a tumor and re-isolated and termed A1-R. A1-R had greater antitumor efficacy and could cure breast, prostate, pancreatic, and lung tumors in nude mouse models.

Citation Download Citation

Robert M. Hoffman, Katsuhiro Hayashi, and Ming Zhao "Therapeutic targeting of tumors with imageable GFP-expressing Salmonella typhimurium auxotrophic mutants", Proc. SPIE 6868, Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes, 68680K (13 February 2008); https://doi.org/10.1117/12.772067

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