Silicon nanocrystals as efficient photosensitizer of singlet oxygen for biomedical applications

V. Yu. Timoshenko; L. A. Osminkina; A. S. Vorontsov; Yu. V. Ryabchikov; M. B. Gongalsky; A. I. Efimova; E. A. Konstantinova; T. Yu. Bazylenko; P. K. Kashkarov; A. A. Kudriavtsev

doi:10.1117/12.729523

25 April 2007 Silicon nanocrystals as efficient photosensitizer of singlet oxygen for biomedical applications

V. Yu. Timoshenko, L. A. Osminkina, A. S. Vorontsov, Yu. V. Ryabchikov, M. B. Gongalsky, A. I. Efimova, E. A. Konstantinova, T. Yu. Bazylenko, P. K. Kashkarov, A. A. Kudriavtsev

Author Affiliations +

Proceedings Volume 6606, Advanced Laser Technologies 2006; 66061E (2007) https://doi.org/10.1117/12.729523
Event: Advanced Laser Technologies 2006, 2006, Brasov, Romania

Abstract

Luminescent silicon nanocrystals (nc-Si) are shown to be efficient photosensitizers of singlet oxygen (SO) generation. Photoluminescence (PL) spectroscopy method is used to study the mechanism and efficiency of the SO photosensitization in gaseous and aqueous ambiences. In vitro experiments demonstrated that the SO, photosensitized by nc-Si dispersed in nutrient solutions, could kill cancer cells. This finding opens a broad opportunity for biomedical applications of nc-Si, e.g. for the photodynamic therapy of cancer or antibacterial treatments.

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V. Yu. Timoshenko, L. A. Osminkina, A. S. Vorontsov, Yu. V. Ryabchikov, M. B. Gongalsky, A. I. Efimova, E. A. Konstantinova, T. Yu. Bazylenko, P. K. Kashkarov, and A. A. Kudriavtsev "Silicon nanocrystals as efficient photosensitizer of singlet oxygen for biomedical applications", Proc. SPIE 6606, Advanced Laser Technologies 2006, 66061E (25 April 2007); https://doi.org/10.1117/12.729523

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