Optical spectroscopic studies of animal skin used in modeling of human cutaneous tissue

E. Drakaki; M. Makropoulou; A. A. Serafetinides; E. Borisova; L. Avramov; J. A. Sianoudis

doi:10.1117/12.727723

13 March 2007 Optical spectroscopic studies of animal skin used in modeling of human cutaneous tissue

E. Drakaki, M. Makropoulou, A. A. Serafetinides, E. Borisova, L. Avramov, J. A. Sianoudis

Proceedings Volume 6604, 14th International School on Quantum Electronics: Laser Physics and Applications; 66042K (2007) https://doi.org/10.1117/12.727723
Event: 14th International School on Quantum Electronics: Laser Physics and Applications, 2006, Sunny Beach, Bulgaria

Abstract

Optical spectroscopy and in particular laser-induced autofluorescence spectroscopy (LIAFS) and diffuse reflectance spectroscopy (DRS), provide excellent possibilities for real-time, noninvasive diagnosis of different skin tissue pathologies. However, the introduction of optical spectroscopy in routine medical practice demands a statistically important data collection, independent from the laser sources and detectors used. The scientists collect databases either from patients, in vivo, or they study different animal models to obtain objective information for the optical properties of various types of normal and diseased tissue. In the present work, the optical properties (fluorescence and reflectance) of two animal skin models are investigated. The aim of using animal models in optical spectroscopy investigations is to examine the statistics of the light induced effects firstly on animals, before any extrapolation effort to humans. A nitrogen laser (&lgr;=337.1 nm) was used as an excitation source for the autofluorescence measurements, while a tungsten-halogen lamp was used for the reflectance measurements. Samples of chicken and pig skin were measured in vitro and were compared with results obtained from measurements of normal human skin in vivo. The specific features of the measured reflectance and fluorescence spectra are discussed, while the limits of data extrapolation for each skin type are also depicted.

Citation Download Citation

E. Drakaki, M. Makropoulou, A. A. Serafetinides, E. Borisova, L. Avramov, and J. A. Sianoudis "Optical spectroscopic studies of animal skin used in modeling of human cutaneous tissue", Proc. SPIE 6604, 14th International School on Quantum Electronics: Laser Physics and Applications, 66042K (13 March 2007); https://doi.org/10.1117/12.727723

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