Assessment of diffusion coefficient of glycerol into the skin ex vivo

Anna A. Gavrilova; Alexander B. Pravdin; Valery V. Tuchin; Gregory B. Altshuler; Ilya V. Yaroslavsky

doi:10.1117/12.741500

1 May 2007 Assessment of diffusion coefficient of glycerol into the skin ex vivo

Anna A. Gavrilova, Alexander B. Pravdin, Valery V. Tuchin, Gregory B. Altshuler, Ilya V. Yaroslavsky

Proceedings Volume 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine; 65343J (2007) https://doi.org/10.1117/12.741500
Event: Fifth International Conference on Photonics and Imaging in Biology and Medicine, 2006, Wuhan, China

Abstract

In present study we have considered diffusion of immersion agent into the skin through thermally pretreated stratum corneum solving the corresponding diffusion problem. Algorithm of refractive index of interstitial liquid and diffusion coefficient of immersion agent into biotissue estimations at a creation of lattice-like pattern of localized thermal damage islets in the stratum corneum, was develop. Theoretical model which sufficiently describes the influence of immersion agents on skin optical properties was presented. The diffusion coefficient of glycerol into pig skin ex vivo at creating a lattice of islets of damage in the stratum corneum is 0.84±0.08 μm²/s.

Citation Download Citation

Anna A. Gavrilova, Alexander B. Pravdin, Valery V. Tuchin, Gregory B. Altshuler, and Ilya V. Yaroslavsky "Assessment of diffusion coefficient of glycerol into the skin ex vivo", Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 65343J (1 May 2007); https://doi.org/10.1117/12.741500

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