Bolus tracking by cone-beam reconstruction and reprojection

Zikuan Chen; Ruola Ning

doi:10.1117/12.710132

29 March 2007 Bolus tracking by cone-beam reconstruction and reprojection

Zikuan Chen, Ruola Ning

Proceedings Volume 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images; 65111Z (2007) https://doi.org/10.1117/12.710132
Event: Medical Imaging, 2007, San Diego, CA, United States

Abstract

Contrast agent bolus is used in angiography for vascular imaging. The bolus flow through a local region in the bolus wash-in phase can be captured by cone-beam scanning, producing a time series of projection images. During the bolus/blood equilibrium phase, circular cone-beam volume scanning produces a dataset that can be used for vessel (or bolus) volume reconstruction. From a bolus (or vessel) volume, we can depict the vessel anatomy and extract the 3D bolus passageways. For bolus velocity measurements, we need to calculate the 3D bolus pathlength and to determine the time interval indicated by the frame time of the dynamic bolus wash-in images. The cone-beam volume reconstruction allows 3D vessel depiction with isotropic grid resolution, thus facilitating the measurement of 3D vessel lumen and centerline. The timing information of the dynamic bolus flow corresponds to the frame time of the bolus wash-in images. In order to add time divisions to a 3D bolus passageway, we suggest a cone-beam reprojection scheme, which consists of vessel-centerline extraction, cone-beam reprojection, and image registration between reprojected images and wash-in projection images. With the accurate measurements of 3D pathlength and time interval, we can calculate the local blood flow in terms of velocity and flux. Simulations of bolus traveling along a sinuate vessel inside a cylinder are provided.

Citation Download Citation

Zikuan Chen and Ruola Ning "Bolus tracking by cone-beam reconstruction and reprojection", Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65111Z (29 March 2007); https://doi.org/10.1117/12.710132

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