Perfusion analysis using a wide coverage flat-panel volume CT: feasibility study

M. Grasruck; R. Gupta M.D.; B. Reichardt; E. Klotz; B. Schmidt; T. Flohr

doi:10.1117/12.708123

17 March 2007 Perfusion analysis using a wide coverage flat-panel volume CT: feasibility study

M. Grasruck, R. Gupta M.D., B. Reichardt, E. Klotz, B. Schmidt, T. Flohr

Proceedings Volume 6510, Medical Imaging 2007: Physics of Medical Imaging; 65101O (2007) https://doi.org/10.1117/12.708123
Event: Medical Imaging, 2007, San Diego, CA, United States

Abstract

We developed a Flat-panel detector based Volume CT (VCT) prototype scanner with large z-coverage. In that prototype scanner a Varian 4030CB a-Si flat-panel detector was mounted in a multi slice CT-gantry (Siemens Medical Solutions) which provides a 25 cm field of view with 18 cm z-coverage at isocenter. The large volume covered in one rotation can be used for visualization of complete organs of small animals, e.g. rabbits. By implementing a mode with continuous scanning, we are able to reconstruct the complete volume at any point in time during the propagation of a contrast bolus. Multiple volumetric reconstructions over time elucidate the first pass dynamics of a bolus of contrast resulting in 4-D angiography and potentially allowing whole organ perfusion analysis. We studied to which extent pixel based permeability and blood volume calculation with a modified Patlak approach was possible. Experimental validation was performed by imaging evolution of contrast bolus in New Zealand rabbits. Despite the short circulation time of a rabbit, the temporal resolution was sufficient to visually resolve various phases of the first pass of the contrast bolus. Perfusion imaging required substantial spatial smoothing but allowed a qualitative discrimination of different types of parenchyma in brain and liver. If a true quantitative analysis is possible, requires further studies.

Citation Download Citation

M. Grasruck, R. Gupta M.D., B. Reichardt, E. Klotz, B. Schmidt, and T. Flohr "Perfusion analysis using a wide coverage flat-panel volume CT: feasibility study", Proc. SPIE 6510, Medical Imaging 2007: Physics of Medical Imaging, 65101O (17 March 2007); https://doi.org/10.1117/12.708123

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