Microscale biochemical sensors are attractive for in vitro diagnostics and disease management, as well as medical and
biological research applications. Fluorescent sensors, coupling specific glucose-binding proteins with fluorescent readout
methods, have been developed for this purpose. Our work has focused on the development of assembly and packaging
systems for producing micro- and nanoscale sensing components that can be used as implants, intracellular reporters, or
as elements in larger systems. Both hybrid organic/inorganic particles and hollow microshells have been developed to
physically couple the sensing materials together in biocompatible, semipermeable packages. Fabrication details and
sensor characterization are used to demonstrate the potential of these sensor concepts.
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