Depth sensitivity of laser Doppler perfusion imager: quantification based on experiments and Monte Carlo simulations on static and dynamic scattering phantoms

Vinayakrishnan Rajan; Babu Varghese; Ton G van Leeuwen; Wiendelt Steenbergen

doi:10.1117/12.698519

14 February 2007 Depth sensitivity of laser Doppler perfusion imager: quantification based on experiments and Monte Carlo simulations on static and dynamic scattering phantoms

Vinayakrishnan Rajan, Babu Varghese, Ton G van Leeuwen, Wiendelt Steenbergen

Author Affiliations +

Proceedings Volume 6445, Optical Diagnostics and Sensing VII; 644506 (2007) https://doi.org/10.1117/12.698519
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We report on a theoretical/experimental model to predict the depth sensitivity of laser Doppler perfusion imager. Further more we show the quantitative influence of speckles on laser Doppler perfusion imager response to scattering at different depths. The model is based on Monte Carlo simulations and experiments on static and dynamic scattering phantoms made of polystyrene microspehers. The experimental results are in good agreement with our theoretical predictions. The results show that the depth sensitivity of the laser Doppler perfusion imager is influenced by the speckles. The effects are big, especially when a narrow beam is used for measurement. We propose that a correction method should be developed based on speckle size in order to have a reliable blood perfusion information independent of tissue optical properties.

Citation Download Citation

Vinayakrishnan Rajan, Babu Varghese, Ton G van Leeuwen, and Wiendelt Steenbergen "Depth sensitivity of laser Doppler perfusion imager: quantification based on experiments and Monte Carlo simulations on static and dynamic scattering phantoms", Proc. SPIE 6445, Optical Diagnostics and Sensing VII, 644506 (14 February 2007); https://doi.org/10.1117/12.698519

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available