Imiquimod immunotherapy and ALA photodynamic therapy combination for the treatment of genital bowenoid papulosis

Xiu-Li Wang; Hong-Wei Wang; Ming-Xia Guo; Zheng Huang

doi:10.1117/12.698774

13 February 2007 Imiquimod immunotherapy and ALA photodynamic therapy combination for the treatment of genital bowenoid papulosis

Xiu-Li Wang, Hong-Wei Wang, Ming-Xia Guo, Zheng Huang

Author Affiliations +

Proceedings Volume 6438, Biophotonics and Immune Responses II; 643809 (2007) https://doi.org/10.1117/12.698774
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

To investigate the feasibility and efficacy of combination of imiquimod immunotherapy and 5- aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) for the treatment of genital bowenoid papulosis (BP). A total of twenty seven BP patients were randomized into two groups: (I) fifteen patients (12 male and 3 female, age 22-56 years old) were treated with topical application of 5% imiquimod cream (three times a week) and ALA-PDT (100 J/cm² at 100 mW/cm², once a week) for 1-4 times in one week interval. (II) Twelve patients (6 male and 6 female, age 29-58 years old) were treated with CO₂ laser vaporization as a control. Patients were followed up for 3 to 12 months. Results: In combined therapy group, 60% (9/15) patients showed complete remission and only one recurred (11.1%) during follow up. Local side effects included mild erythema, edema, erosion and burning and/or stinging sensation. No systemic side effect was found. In CO₂ laser vaporization group, 83.3% (10/12) patients showed complete remission. However, recurrence occurred in 6 patients (60.0%). Local side effects included mild to moderate edema, erosion, ulceration, delayed healing, prolonged pain and scarring. The difference of recurrence rate between two groups was statistically significant (P < 0.05). Topical application of imiquimod cream and ALA-PDT is safe, effective and associated with low recurrence and less side effect. Its true clinical value needs to be further investigated by a long-term follow-up of large scale trial.

Citation Download Citation

Xiu-Li Wang, Hong-Wei Wang, Ming-Xia Guo, and Zheng Huang "Imiquimod immunotherapy and ALA photodynamic therapy combination for the treatment of genital bowenoid papulosis", Proc. SPIE 6438, Biophotonics and Immune Responses II, 643809 (13 February 2007); https://doi.org/10.1117/12.698774

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