Phantom study on combined cw and time-domain fluorescence mammography

D. Grosenick; O. Steinkellner; A. Hagen; R. Ziegler; T. Nielsen; R. Macdonald; H. Rinneberg

doi:10.1117/12.700973

13 February 2007 Phantom study on combined cw and time-domain fluorescence mammography

D. Grosenick, O. Steinkellner, A. Hagen, R. Ziegler, T. Nielsen, R. Macdonald, H. Rinneberg

Proceedings Volume 6434, Optical Tomography and Spectroscopy of Tissue VII; 64340I (2007) https://doi.org/10.1117/12.700973
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We have carried out phantom studies for optimizing the design of a fluorescence mammograph employing time-domain and cw measurements, for improving data analysis and methods of reconstruction. By scanning pulsed (100 fs) laser radiation across a fluorescent, rectangular breast-like phantom with a spherical inhomogeneity simulating a tumor bearing breast slightly compressed between two parallel glass plates, distributions of times of flight of laser and fluorescence photons were measured in transmission and reflection for various detector arrangements. Absorption coefficients and dye concentrations were reconstructed using perturbation solutions of the diffusion equation at the laser and fluorescence wavelengths. We additionally employed a CCD camera to measure time-integrated intensity of fluorescence and laser radiation transmitted through the phantom. The increased number of projection angles entering the reconstruction improved spatial resolution. Further improvements were obtained when combined cw data and time-resolved remission data were used in the reconstruction.

Citation Download Citation

D. Grosenick, O. Steinkellner, A. Hagen, R. Ziegler, T. Nielsen, R. Macdonald, and H. Rinneberg "Phantom study on combined cw and time-domain fluorescence mammography", Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64340I (13 February 2007); https://doi.org/10.1117/12.700973

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