Novel optical spectroscopy system for breast cancer diagnostics

Natalia Shakhova; Ilya Turchin; Vladislav Kamensky; Ekaterina Sergeeva; German Golubyatnikov; Luiz Da Silva; Usha Kasthuri; Irina Pavlycheva; Svetlana Smetanina; Anna Artifeksova; Sergey Belkov; Gennady Kochemasov

doi:10.1117/12.700656

13 February 2007 Novel optical spectroscopy system for breast cancer diagnostics

Natalia Shakhova, Ilya Turchin, Vladislav Kamensky, Ekaterina Sergeeva, German Golubyatnikov, Luiz Da Silva, Usha Kasthuri, Irina Pavlycheva, Svetlana Smetanina, Anna Artifeksova, Sergey Belkov, Gennady Kochemasov

Author Affiliations +

Proceedings Volume 6430, Advanced Biomedical and Clinical Diagnostic Systems V; 64300N (2007) https://doi.org/10.1117/12.700656
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We report on development of minimally invasive system for immediate diagnostics of breast cancer and on the results of its pilot clinical testing. The system designed by BioTelligent Inc is based on analysis of optical diffusion spectra (ODS) measured by a probe inserted into breast tissue during standard punch biopsy. Analysis of scattered spectra aimed to distinction of benign tumors from malignant ones is done by original procedure of data processing. Clinical testing of the created diagnostic system has been performed by classification of spectra collected from 146 patients with previously detected mammary neoplasms. The data of ODS study in each patient have been compared to the results of histology. The proposed technique has to date demonstrated sensitivity of 96%, specificity of 80% and diagnostic accuracy of 88%. These values are expected to improve as the data sets continue to grow and more sophisticated data processing is employed.

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Natalia Shakhova, Ilya Turchin, Vladislav Kamensky, Ekaterina Sergeeva, German Golubyatnikov, Luiz Da Silva, Usha Kasthuri, Irina Pavlycheva, Svetlana Smetanina, Anna Artifeksova, Sergey Belkov, and Gennady Kochemasov "Novel optical spectroscopy system for breast cancer diagnostics", Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64300N (13 February 2007); https://doi.org/10.1117/12.700656

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