Interstitial photodynamic therapy for primary prostate cancer incorporating real-time treatment dosimetry

Ann Johansson; Johan Axelsson; Johannes Swartling; Thomas Johansson; Sara Pålsson; Johan Stensson; Margret Einarsdóttír; Katarina Svanberg M.D.; Niels Bendsoe; Karl Mikael Kälkner; Sten Nilsson; Sune Svanberg; Stefan Andersson-Engels

doi:10.1117/12.699903

27 February 2007 Interstitial photodynamic therapy for primary prostate cancer incorporating real-time treatment dosimetry

Ann Johansson, Johan Axelsson, Johannes Swartling, Thomas Johansson, Sara Pålsson, Johan Stensson, Margret Einarsdóttír, Katarina Svanberg M.D., Niels Bendsoe, Karl Mikael Kälkner, Sten Nilsson, Sune Svanberg, Stefan Andersson-Engels

Author Affiliations +

Proceedings Volume 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI; 64270O (2007) https://doi.org/10.1117/12.699903
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Photodynamic therapy (PDT) for the treatment of prostate cancer has been demonstrated to be a safe treatment option capable of inducing tissue necrosis and decrease in prostate specific antigen (PSA). Research groups report on large variations in treatment response, possibly due to biological variations in tissue composition and short-term response to the therapeutic irradiation. Within our group, an instrument for interstitial PDT on prostate tissue that incorporates realtime treatment feedback is being developed. The treatment protocol consists of two parts. The first part incorporates the pre-treatment plan with ultrasound investigations, providing the geometry for the prostate gland and surrounding risk organs, an iterative random-search algorithm to determine near-optimal fiber positions within the reconstructed geometry and a Block-Cimmino optimization algorithm for predicting individual fiber irradiation times. During the second part, the therapeutic light delivery is combined with measurements of the light transmission signals between the optical fibers, thus monitoring the tissue effective attenuation coefficient by means of spatially resolved spectroscopy. These data are then used as input for repeated runs of the Block-Cimmino optimization algorithm. Thus, the irradiation times for individual fibers are updated throughout the treatment in order to compensate for the influence of changes in tissue composition on the light distribution at the therapeutic wavelength.

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Ann Johansson, Johan Axelsson, Johannes Swartling, Thomas Johansson, Sara Pålsson, Johan Stensson, Margret Einarsdóttír, Katarina Svanberg M.D., Niels Bendsoe, Karl Mikael Kälkner, Sten Nilsson, Sune Svanberg, and Stefan Andersson-Engels "Interstitial photodynamic therapy for primary prostate cancer incorporating real-time treatment dosimetry", Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 64270O (27 February 2007); https://doi.org/10.1117/12.699903

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