Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers

Valeria Garbin; Dan Cojoc; Enrico Ferrari; Enzo Di Fabrizio; Marlies Overvelde; Michel Versluis; Sander van der Meer; Nico de Jong; Detlef Lohse

doi:10.1117/12.680576

11 September 2006 Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers

Valeria Garbin, Dan Cojoc, Enrico Ferrari, Enzo Di Fabrizio, Marlies Overvelde, Michel Versluis, Sander van der Meer, Nico de Jong, Detlef Lohse

Author Affiliations +

Proceedings Volume 6326, Optical Trapping and Optical Micromanipulation III; 63261V (2006) https://doi.org/10.1117/12.680576
Event: SPIE Optics + Photonics, 2006, San Diego, California, United States

Abstract

Optical tweezers enable non-destructive, contact-free manipulation of ultrasound contrast agent (UCA) microbubbles, which are used in medical imaging for enhancing the echogenicity of the blood pool and to quantify organ perfusion. The understanding of the fundamental dynamics of ultrasound-driven contrast agent microbubbles is a first step for exploiting their acoustical properties and to develop new diagnostic and therapeutic applications. In this respect, optical tweezers can be used to study UCA microbubbles under controlled and repeatable conditions, by positioning them away from interfaces and from neighboring bubbles. In addition, a high-speed imaging system is required to record the dynamics of UCA microbubbles in ultrasound, as their oscillations occur on the nanoseconds timescale. In this work, we demonstrate the use of an optical tweezers system combined with a high-speed camera capable of 128-frame recordings at up to 25 million frames per second (Mfps), for the study of individual UCA microbubble dynamics as a function of the distance from solid interfaces.

Citation Download Citation

Valeria Garbin, Dan Cojoc, Enrico Ferrari, Enzo Di Fabrizio, Marlies Overvelde, Michel Versluis, Sander van der Meer, Nico de Jong, and Detlef Lohse "Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers", Proc. SPIE 6326, Optical Trapping and Optical Micromanipulation III, 63261V (11 September 2006); https://doi.org/10.1117/12.680576

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