Opto-bio-fluidic modeling of bioanalytical and biomedical microdevices

Andrzej J. Przekwas; Zbigniew Sikorski

doi:10.1117/12.681384

11 September 2006 Opto-bio-fluidic modeling of bioanalytical and biomedical microdevices

Proceedings Volume 6326, Optical Trapping and Optical Micromanipulation III; 63261N (2006) https://doi.org/10.1117/12.681384
Event: SPIE Optics + Photonics, 2006, San Diego, California, United States

Abstract

Optical technology is rapidly finding novel applications in several exiting bioanalytical, biological, and biomedical applications. Optical beams are increasingly used for bio-fluidic sample manipulation in BioMEMS devices replacing convectional mechanical, electrostatic, and electrokinetic methods. This paper presents novel multiphysics computational approach for modeling optical interaction with fluidic, thermal, mechanical, and biological processes. We present a model of optical manipulation of particles and biological cells with laser beams. Computational results are compared to available experimental data from laboratory experiments and from practical engineered optical bio microdevices. The modeling approach is demonstrated on selected specific applications of optical manipulation of micro spheres, micro cylinders, and optical manipulation and sorting of biological cells in microfluidic cytometers.

Citation Download Citation

Andrzej J. Przekwas and Zbigniew Sikorski "Opto-bio-fluidic modeling of bioanalytical and biomedical microdevices", Proc. SPIE 6326, Optical Trapping and Optical Micromanipulation III, 63261N (11 September 2006); https://doi.org/10.1117/12.681384

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