Image-based analysis of the internal microstructure of bone replacement scaffolds fabricated by 3D printing

Stephan H. Irsen; Barbara Leukers; Björn Bruckschen; Carsten Tille; Hermann Seitz; Felix Beckmann; Bert Müller

doi:10.1117/12.681149

7 September 2006 Image-based analysis of the internal microstructure of bone replacement scaffolds fabricated by 3D printing

Stephan H. Irsen, Barbara Leukers, Björn Bruckschen, Carsten Tille, Hermann Seitz, Felix Beckmann, Bert Müller

Author Affiliations +

Proceedings Volume 6318, Developments in X-Ray Tomography V; 631809 (2006) https://doi.org/10.1117/12.681149
Event: SPIE Optics + Photonics, 2006, San Diego, California, United States

Abstract

Rapid Prototyping and especially the 3D printing, allows generating complex porous ceramic scaffolds directly from powders. Furthermore, these technologies allow manufacturing patient-specific implants of centimeter size with an internal pore network to mimic bony structures including vascularization. Besides the biocompatibility properties of the base material, a high degree of open, interconnected porosity is crucial for the success of the synthetic bone graft. Pores with diameters between 100 and 500 μm are the prerequisite for vascularization to supply the cells with nutrients and oxygen, because simple diffusion transport is ineffective. The quantification of porosity on the macro-, micro-, and nanometer scale using well-established techniques such as Hg-porosimetry and electron microscopy is restricted. Alternatively, we have applied synchrotron-radiation-based micro computed tomography (SRμCT) to determine the porosity with high precision and to validate the macroscopic internal structure of the scaffold. We report on the difficulties in intensity-based segmentation for nanoporous materials but we also elucidate the power of SRμCT in the quantitative analysis of the pores at the different length scales.

Citation Download Citation

Stephan H. Irsen, Barbara Leukers, Björn Bruckschen, Carsten Tille, Hermann Seitz, Felix Beckmann, and Bert Müller "Image-based analysis of the internal microstructure of bone replacement scaffolds fabricated by 3D printing", Proc. SPIE 6318, Developments in X-Ray Tomography V, 631809 (7 September 2006); https://doi.org/10.1117/12.681149

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