Bio-medical imaging with a terahertz quantum cascade laser

Seongsin M. Kim; Fariba Hatami; Allison W. Kurian M.D.; James Ford; James S. Harris; Giacomo Scalari; Marcella Giovannini; Nicolas Hoyler; Jerome Faist; Geoff Harris

doi:10.1117/12.647233

28 February 2006 Bio-medical imaging with a terahertz quantum cascade laser

Seongsin M. Kim, Fariba Hatami, Allison W. Kurian M.D., James Ford, James S. Harris, Giacomo Scalari, Marcella Giovannini, Nicolas Hoyler, Jerome Faist, Geoff Harris

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Proceedings Volume 6095, Nanobiophotonics and Biomedical Applications III; 60950B (2006) https://doi.org/10.1117/12.647233
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

We investigated and demonstrated bio-medical imaging using a THz quantum cascade laser. With the THz quantum cascade laser (QCL) at 3.8 THz, we obtained large dynamic range and high spatial resolution in the transmission imaging technique. The various tissues images, such as lung, liver, and brain sections from the laboratory mouse were obtained and studied. The most important factor for this imaging scheme is to obtain high contrast with different absorption characteristics in tissues. We explored distinct images from the fat, muscles and tendon from the freshly cut tissues and investigated absorption coefficient and compared with FTIR measurement. We also demonstrated the image of distinct region of tumors progressed and normal tissues using this technique. The comparison of frequency dependent medical imaging with utilizing different wavelength of QCLs has been addressed.

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Seongsin M. Kim, Fariba Hatami, Allison W. Kurian M.D., James Ford, James S. Harris, Giacomo Scalari, Marcella Giovannini, Nicolas Hoyler, Jerome Faist, and Geoff Harris "Bio-medical imaging with a terahertz quantum cascade laser", Proc. SPIE 6095, Nanobiophotonics and Biomedical Applications III, 60950B (28 February 2006); https://doi.org/10.1117/12.647233

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KEYWORDS

Terahertz radiation

Tissues

Quantum cascade lasers

Liver

Absorption

Brain

Bone

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