Advances in the development of a novel method to be used in proteomics using gold nanobeads

Heidelinde R. C. Dietrich; Ian T. Young; Yuval Garini

doi:10.1117/12.645908

27 February 2006 Advances in the development of a novel method to be used in proteomics using gold nanobeads

Heidelinde R. C. Dietrich, Ian T. Young, Yuval Garini

Proceedings Volume 6092, Ultrasensitive and Single-Molecule Detection Technologies; 60920C (2006) https://doi.org/10.1117/12.645908
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

The study of DNA-protein interactions is gaining increased attention due to their importance in cellular processes. Only a well-functioning interaction guaranties that such a process can take place without errors. So far, only a small percentage of these interactions have been unraveled, partially due to their complexity but also due to the fact that there are only a few techniques that permit the study of these interactions. In this report we describe the development of a research tool based on tethered bead motion and Resonance Light Scattering (RLS) from gold beads. This method permits the study of DNA-protein interactions and the screening of proteins binding to a specific DNA sequence.

Citation Download Citation

Heidelinde R. C. Dietrich, Ian T. Young, and Yuval Garini "Advances in the development of a novel method to be used in proteomics using gold nanobeads", Proc. SPIE 6092, Ultrasensitive and Single-Molecule Detection Technologies, 60920C (27 February 2006); https://doi.org/10.1117/12.645908

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