NAOMI: nanoparticle assisted optical molecular imaging

Dirk J. Faber; Mirjam E. J. van Velthoven; Martijn de Bruin; Maurice C. G. Aalders; Frank D. Verbraak; Christina Graf; Ton G. van Leeuwen

doi:10.1117/12.645316

20 February 2006 NAOMI: nanoparticle assisted optical molecular imaging

Dirk J. Faber, Mirjam E. J. van Velthoven, Martijn de Bruin, Maurice C. G. Aalders, Frank D. Verbraak, Christina Graf, Ton G. van Leeuwen

Author Affiliations +

Proceedings Volume 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X; 607905 (2006) https://doi.org/10.1117/12.645316
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Our first steps towards nanoparticle assisted, optical molecular imaging (NAOMI) using OCT as the imaging modality are presented. We derive an expression to estimate the sensitivity of this technique. We propose to use nanoparticles based on biodegradable polymers, loaded with suitable dyes as contrast agent, and outline a method for establishing their desired optical properties prior to synthesis. This report presents preliminary results of our investigation on the use of nanoshells to serve as contrast agents We injected nanoshells with specific contrast features in the 800 nm wavelength region in excised porcine eyes. The nanoshells showed up as bright reflecting structures in the OCT images, which confirm their potential as contrast agents.

Citation Download Citation

Dirk J. Faber, Mirjam E. J. van Velthoven, Martijn de Bruin, Maurice C. G. Aalders, Frank D. Verbraak, Christina Graf, and Ton G. van Leeuwen "NAOMI: nanoparticle assisted optical molecular imaging", Proc. SPIE 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, 607905 (20 February 2006); https://doi.org/10.1117/12.645316

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