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We at Fibersense and Signals are pleased to report the research and development of novel multiple-wavelength and multi-spectral techniques and devices to distinguish glucose from a comprehensive panel of other spectrally evident and interactive blood components such as: albumin, salts, urea and amino acids. A highly selective, glucose-specific bio-spectroscopic technique has been developed to provide clinically-relevant information regarding glucose concentrations. Furthermore, this work has resulted in novel multi-wavelength technology and techniques for the non-invasive detection and continuous non-invasive monitoring of blood glucose levels. As a developer of fiber optic, photonic and laser-related products as well as optical test and measurement instrumentation, Fibersense has used an essentially problem-solving approach to address practical issues that have long hindered progress in non-invasive glucose detection and monitoring, and has overcome the limitations of previous techniques. We have fabricated and optimized optical sources for this application, specifically with respect to useful wavelength ranges, transmittance rates, reflectance, absorption and scattering/dispersion. We have also characterized a multi-wavelength combination and procedure to address and screen out the spectral overlapping of glucose and common blood compounds within physiological criteria. Furthermore, attention has been paid to the viable optical launching of effective wavelengths and the ultra-sensitive optical pick up and detection within very tight wavelength margins to generate useful blood glucose information. The culmination of these techniques has been the design and fabrication of miniaturized, non-invasive multi-channel glucose sensors with dynamic self-calibration features for use in in vitro and experimental in vivo applications.
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