The metabolization of ALA taken orally and its effect on skin and tumors

Jing Zhu; Hui-Guo Zhang; Mei-Jue Zhang; Xiaoqing Bao; Min Yan; Liping Lu

doi:10.1117/12.639240

11 September 2006 The metabolization of ALA taken orally and its effect on skin and tumors

Jing Zhu, Hui-Guo Zhang, Mei-Jue Zhang, Xiaoqing Bao, Min Yan, Liping Lu

Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 596712 (2006) https://doi.org/10.1117/12.639240
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China

Abstract

Objective: Research on the metabolize of ALA (after take orally) on skin and tumor, to find the best dose and diagnostic time of ALA after take orally Methods: Measure the fluorescence spectra of tumor and skin with different dose of ALA take orally (20mg/kg, 40mg/kg, 60mg/kg, 80mg/kg, 100mg/kg) and different time after ALA take orally (1h, 2h, 4h, 6h, 8h, 10h, 12h, 24h, 48h) when irradiated by laser. By analyzing the spectrum of fluorescence with optical multi-channel analyzer (OMA), also the fluorescence intensity should be normalized. Result: The best ratio (I_tumor/I_nomal) of skin was obtained at 60mg/kg, of ALA take orally and 6-8h after ALA take orally Conclusion: Measure the fluorescence spectrum of tumor and skin by using optical multi-channel analyzer (OMA). The best dose was 60mg/kg of ALA take orally and the measure time was 6-8 hours after ALA taking orally.

Citation Download Citation

Jing Zhu, Hui-Guo Zhang, Mei-Jue Zhang, Xiaoqing Bao, Min Yan, and Liping Lu "The metabolization of ALA taken orally and its effect on skin and tumors", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 596712 (11 September 2006); https://doi.org/10.1117/12.639240

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