Implementing in vasion neutron capture therapy (INCT) using capillary neutron optical systems (CNOS) assessment

G. I. Borisov; M. A. Kumakhov; R. I. Kondratenko; R. A. Spryshkova

doi:10.1117/12.637989

6 December 2006 Implementing in vasion neutron capture therapy (INCT) using capillary neutron optical systems (CNOS) assessment

G. I. Borisov, M. A. Kumakhov, R. I. Kondratenko, R. A. Spryshkova

Author Affiliations +

Proceedings Volume 5943, X-ray and Neutron Capillary Optics II; 59430T (2006) https://doi.org/10.1117/12.637989
Event: X-ray and Neutron Capillary Optics II, 2004, Zvenigorod, Russian Federation

Abstract

During LNCT the exposed object represents a practically ideal trap for neutrons In this instance, the number of neutrons that entered the object through the inlet hole is equal to the number of nuclear reactions of their absorption. Using this model and nuclear data about all considered nuclides for a biological tissue, the following INCT characteristics were theoretically calculated with regard to introduction of dosage-forming preparations based on different concentrations of lOB, l57Gd and 235U nuclides: - effective masses irradiated by thermal neutrons, - energies absorbed in the object for one thermal neutron entered, - partial content of basic dosage-forming reactions, - partial content of absorbed dosage of thermal neutrons from basic dosage-forming reactions, - quantity of thermal neutrons needed to create a total absorbed dosage of 5 Gr within the focal spot area of 0,28 cm², - number of nuclear reactions with dosage-forming nuclides of preparations per one cell based on the cell volume of 7x7x7 m. It follows from the data obtained that dosage-forming nuclide ¹⁰B is not only the optimal but also the only one suitable for INCT. Using the obtained outcome, one can assess parameters of capillary neutron optical systems (CNOS) that are pre-requisite to implement INCT at particular experimental channels (EC) of research nuclear reactors.

Citation Download Citation

G. I. Borisov, M. A. Kumakhov, R. I. Kondratenko, and R. A. Spryshkova "Implementing in vasion neutron capture therapy (INCT) using capillary neutron optical systems (CNOS) assessment", Proc. SPIE 5943, X-ray and Neutron Capillary Optics II, 59430T (6 December 2006); https://doi.org/10.1117/12.637989

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KEYWORDS

Tissues

Capillaries

Tissue optics

Absorption

Data modeling

Gadolinium

Tumors

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