Relationship between plaque development and local hemodynamics in coronary arteries

Andreas Wahle; John J. Lopez; Mark Eric Olszewski; Sarah C. Vigmostad; Kathleen C. Braddy; Theresa M. H. Brennan; Syed W. Bokhari M.D.; J. Gray Bennett M.D.; Elizabeth M. Holper; James D. Rossen; Krishnan B. Chandran; Milan Sonka

doi:10.1117/12.596902

14 April 2005 Relationship between plaque development and local hemodynamics in coronary arteries

Andreas Wahle, John J. Lopez, Mark Eric Olszewski, Sarah C. Vigmostad, Kathleen C. Braddy, Theresa M. H. Brennan, Syed W. Bokhari M.D., J. Gray Bennett M.D., Elizabeth M. Holper, James D. Rossen, Krishnan B. Chandran, Milan Sonka

Author Affiliations +

Proceedings Volume 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images; (2005) https://doi.org/10.1117/12.596902
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

The mechanisms of plaque development in coronary arteries are not yet completely understood. Vessel geometry influences the local hemodynamics within a vessel, and the resulting wall shear stress in turn influences plaque development. Previously, we showed in-vivo that plaque tends to accumulate more on the inner curvature of a vessel than on its outer curvature. While vessel curvature is preserved during plaque progression, the local wall shear stresses change with lumen narrowing. The aim of this study was to test how the hypothesis that locations of low wall shear stress coincide with circumferentially larger plaque accumulation depends on vascular remodeling with or without lumen narrowing. We have analyzed 39 in-vivo intravascular-ultrasound pullbacks, for which geometrically accurate 3-D models were obtained by fusion with x-ray angiography. Distorting subsegments (branches, calcifications, stents) were discarded, and the relative number of vessel locations was determined within a 10-40% area-stenosis range. This range corresponds to compensatory enlargement (outward or positive vessel remodeling), but not yet lumen narrowing, and these vessel segments were a focus of our study. For each segment, we determined the relative number of vessel locations for which circumferentially low wall shear stress coincided with larger plaque thickness and vice versa. The inverse association between wall shear stress and plaque thickness was significantly more pronounced (p<0.005) in vessel cross sections exhibiting compensatory enlargement without luminal narrowing than when the full spectrum of vessel stenosis severity was considered. Thus, the hypothesis is supported more in subsegments with less developed disease.

Citation Download Citation

Andreas Wahle, John J. Lopez, Mark Eric Olszewski, Sarah C. Vigmostad, Kathleen C. Braddy, Theresa M. H. Brennan, Syed W. Bokhari M.D., J. Gray Bennett M.D., Elizabeth M. Holper, James D. Rossen, Krishnan B. Chandran, and Milan Sonka "Relationship between plaque development and local hemodynamics in coronary arteries", Proc. SPIE 5746, Medical Imaging 2005: Physiology, Function, and Structure from Medical Images, (14 April 2005); https://doi.org/10.1117/12.596902

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available