Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution

B. T. Cox; S. R. Arridge; K. P. Kostli; P. C. Beard

doi:10.1117/12.597190

25 April 2005 Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution

B. T. Cox, S. R. Arridge, K. P. Kostli, P. C. Beard

Author Affiliations +

Proceedings Volume 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics; (2005) https://doi.org/10.1117/12.597190
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Photoacoustic imaging, which generates a map of the initial acoustic pressure distribution generated by a short laser pulse, has been demonstrated by several authors. Quantitative photoacoustic imaging takes this one stage further to produce a map of the distribution of an optical property of the tissue, in this case absorption, which can then be related to a physiological parameter. In this technique, the initial pressure distribution is assumed to be proportional to the absorbed laser energy density. A model of light transport in scattering media is then used to estimate the distribution of optical properties that would result in such a pattern of absorbed energy. The light model used a finite element implementation of the diffusion equation (with the delta-E(3) approximation included to improve the accuracy at short distances inside the scattering medium). An algorithm which applies this model iteratively and converges on a quantitative estimate of the optical absorption distribution is described. 2D examples using simulated data (initial pressure maps) with and without noise are shown to converge quickly and accurately.

Citation Download Citation

B. T. Cox, S. R. Arridge, K. P. Kostli, and P. C. Beard "Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution", Proc. SPIE 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, (25 April 2005); https://doi.org/10.1117/12.597190

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