Infrared fiber optic spectroscopy: a novel tool for skin diagnosis

Ilan Goldberg; Aushrat Shushan; Sarah Brenner; Boaz Nadler; Yosef Raichlin; Evgeny Shulzinger; Leah Gerber; Abraham Katzir

doi:10.1117/12.528961

1 July 2004 Infrared fiber optic spectroscopy: a novel tool for skin diagnosis

Ilan Goldberg, Aushrat Shushan, Sarah Brenner, Boaz Nadler, Yosef Raichlin, Evgeny Shulzinger, Leah Gerber, Abraham Katzir

Author Affiliations +

Proceedings Volume 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies; (2004) https://doi.org/10.1117/12.528961
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Fiber Evanescent Wave Spectroscopy (FEWS) is a very useful method for non-invasive and non-destructive biomedical diagnosis. We have developed a FEWS system that makes use of a Fourier Transform Infrared (FTIR) spectrometer and IR transmitting AgBr_xCl_1-_x fibers. The FTIR-FEWS system is compact and easy to use, and it is ideal for the study of the spectroscopy of the skin in the mid-IR. The evanescent wave penetration depth in the mid-IR is comparable with the thickness of the stratum corneum, and therefore the vibrational spectra of lipids, proteins and water can be easily analyzed. We have used FTIR-FEWS for a clinical study of the skin of 60 patients, who had some suspicious skin lesions. Preliminary measurements were carried out both on the lesion and on neighboring healthy areas of the skin, showing some differences in the IR absorption. More data is needed in order to determine the possibility of diagnosis of skin cancer and its type from mid-IR spectral data.

Citation Download Citation

Ilan Goldberg, Aushrat Shushan, Sarah Brenner, Boaz Nadler, Yosef Raichlin, Evgeny Shulzinger, Leah Gerber, and Abraham Katzir "Infrared fiber optic spectroscopy: a novel tool for skin diagnosis", Proc. SPIE 5321, Biomedical Vibrational Spectroscopy and Biohazard Detection Technologies, (1 July 2004); https://doi.org/10.1117/12.528961

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available