Singlet oxygen generation and dark toxicity of a nido- and a closo-carboranylporphyrin

Maria Graca H. Vicente; Vijay Gottumukkala; Anura Wickramasinghe; Maxim Anikovsky; Michael A. J. Rodgers

doi:10.1117/12.531903

14 June 2004 Singlet oxygen generation and dark toxicity of a nido- and a closo-carboranylporphyrin

Maria Graca H. Vicente, Vijay Gottumukkala, Anura Wickramasinghe, Maxim Anikovsky, Michael A. J. Rodgers

Proceedings Volume 5315, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII; (2004) https://doi.org/10.1117/12.531903
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

The dark toxicity and singlet oxygen quantum yields of the zinc(II) complexes of the nido- and closo-carboranylporphyrins 4 and 5 are reported. Both carboranylporphyrins show very low toxicity towards V79 hamster lung fibroblast cells (IC₅₀ > 500 μM), display similar absorption and fluorescence emission spectra, and are efficient producers of singlet oxygen (quantum uilds of 0.72 in CD₃OD and 0.45 in CHCl₃ were determined for 4 and 5, respectively). Our results indicate that the presence of nido- or closo-carborane cages bound via methylene linkages to the meso-phenyl groups, do not substantially alter the photosensitizing properties of porphyrin macrocycles. It is suggested that carboanylporphyrins could have dual application in the boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) treatment of malignant brain tumors.

Citation Download Citation

Maria Graca H. Vicente, Vijay Gottumukkala, Anura Wickramasinghe, Maxim Anikovsky, and Michael A. J. Rodgers "Singlet oxygen generation and dark toxicity of a nido- and a closo-carboranylporphyrin", Proc. SPIE 5315, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII, (14 June 2004); https://doi.org/10.1117/12.531903

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