CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 5314 > Article
Paper
13 July 2004 Quantification of photoreceptor layer thickness in different macular pathologies using ultrahigh-resolution optical coherence tomography
Wolfgang Drexler, Boris Hermann, Angelika Unterhuber, Harald Sattmann, Matthias Wirtitsch, Michael Stur, Christoph Scholda, Erdem Ergun, Elisabeth Anger, Tony H. Ko, Christian Schubert, Peter K. Ahnelt, James G. Fujimoto, Adolf F. Fercher
Author Affiliations +
Proceedings Volume 5314, Ophthalmic Technologies XIV; (2004) https://doi.org/10.1117/12.528646
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States
Abstract
In vivo ultrahigh resolution ophthalmic OCT has been performed in more than 300 eyes of 200 patients with several retinal pathologies, demonstrating unprecedented visualization of all major intraretinal layers, in particular the photoreceptor layer. Visualization as well as quantification of the inner and outer segment of the photoreceptor layer especially in the foveal region has been acvhieved. In normal subjects the photoreceptor layer thickness in the center of the fovea is about of 90 μm, approximately equally distributed to the inner and the outer photoreceptor segment. In the parafoveal region this thickness is reduced to ~50 μm (~30 μm for the inner and ~20 μm for the outer segment). This is in good agreement with well known increase of cone outer segments in the central foveal region. Photoreceptor layer impairment in different macular pathologies like macular hole, central serous chorioretinopathy, age related macular degeneration, foveomacular dystrophies, Stargardt dystrophy as well as retinitis pigmentosa has been investigated. Photoreceptor layer loss significantly correlated with visual acuity (R2 = 0.6, p < 0.001) and microperimetry findings for the first time in 22 eyes with Stargardt dystrophy. Visualization and quantification of photoreceptor inner and outer segment using ultrahigh resolution OCT has the potential to improve early ophthalmic diagnosis, contributes to a better understanding of pathogenesis of retinal diseases as well as might have impact in the development and monitoring of novel therapy approaches.
© (2004) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Wolfgang Drexler, Boris Hermann, Angelika Unterhuber, Harald Sattmann, Matthias Wirtitsch, Michael Stur, Christoph Scholda, Erdem Ergun, Elisabeth Anger, Tony H. Ko, Christian Schubert, Peter K. Ahnelt, James G. Fujimoto, and Adolf F. Fercher "Quantification of photoreceptor layer thickness in different macular pathologies using ultrahigh-resolution optical coherence tomography", Proc. SPIE 5314, Ophthalmic Technologies XIV, (13 July 2004); https://doi.org/10.1117/12.528646
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 6 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Optical coherence tomography
Visualization
Image segmentation
Retina
Image resolution
Pathology
In vivo imaging
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top