CMOS focal-plane-array for analysis of enzymatic reaction in system-on-chip spectrophotometer

Dong Wang; Chanki Ha; Chan Beum Park; Youngjoong Joo

doi:10.1117/12.526364

7 June 2004 CMOS focal-plane-array for analysis of enzymatic reaction in system-on-chip spectrophotometer

Dong Wang, Chanki Ha, Chan Beum Park, Youngjoong Joo

Proceedings Volume 5301, Sensors and Camera Systems for Scientific, Industrial, and Digital Photography Applications V; (2004) https://doi.org/10.1117/12.526364
Event: Electronic Imaging 2004, 2004, San Jose, California, United States

Abstract

A CMOS focal-plane-array is designed for the high-throughput analysis of enzymatic reaction in on-chip spectrophotometer system. One of potential applications of the presented prototype system is to perform enzymatic analysis of biocompounds contained in blood. This function normally requires an expensive diode-array spectrophotometer, but it is possible to perform high throughput analysis with low budget if the spectrophotometer system is scaled down to a chip. The CMOS active pixel sensor array can cover a layer of polydimethylsiloxane (PDMS) forming the microfluidic channels and the substrate solution for enzymatic reaction can be injected into the channels by capillary force. Under room light, the underneath CMOS active pixel sensor with 40 x 40 pixels detect the gray levels of the fluid’s color. Inside the image sensor chip (size: 3mm x 3mm), the pixels of the same column share the same sample and hold circuits. The analog signals from 40 columns are multiplexed into one input feeding an on-chip 8 bits dual-slope analog to digital converter. The color change can be displayed on the external monitor by using a data acquisition card and personal computer.

Citation Download Citation

Dong Wang, Chanki Ha, Chan Beum Park, and Youngjoong Joo "CMOS focal-plane-array for analysis of enzymatic reaction in system-on-chip spectrophotometer", Proc. SPIE 5301, Sensors and Camera Systems for Scientific, Industrial, and Digital Photography Applications V, (7 June 2004); https://doi.org/10.1117/12.526364

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