Raman spectroscopy in the assessment of breast cancer and axillary lymph node metastases

Jenny Smith; Catherine Kendall; Jay Christie-Brown; Alastair Sammon; Nicholas Stone

doi:10.1117/12.500472

8 October 2003 Raman spectroscopy in the assessment of breast cancer and axillary lymph node metastases

Jenny Smith, Catherine Kendall, Jay Christie-Brown, Alastair Sammon, Nicholas Stone

Proceedings Volume 5141, Diagnostic Optical Spectroscopy in Biomedicine II; (2003) https://doi.org/10.1117/12.500472
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

Raman Spectroscopy is an optical diagnostic technique applied in this study to characterise breast tissue by biochemical signature spectra. In cross-validated results, Raman Spectroscopy identifies invasive breast carcinoma with 75 - 97% agreement with Histology opinion. Axillary lymph nodes from patients with breast carcinoma were mapped with confocal Raman Spectroscopy and colour-weighted principal component analysis (PCA) images were used to identify local biochemical features and correlate these with parallel section slides analysed with routine histology.

Citation Download Citation

Jenny Smith, Catherine Kendall, Jay Christie-Brown, Alastair Sammon, and Nicholas Stone "Raman spectroscopy in the assessment of breast cancer and axillary lymph node metastases", Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); https://doi.org/10.1117/12.500472

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