Employing microtechnology for noninvasive determination of local blood oxygen saturation based on tissue remission spectra

Gerd Ehret; Ignaz Thiemann; Eduard Reithmeier

doi:10.1117/12.500052

8 October 2003 Employing microtechnology for noninvasive determination of local blood oxygen saturation based on tissue remission spectra

Gerd Ehret, Ignaz Thiemann, Eduard Reithmeier

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Proceedings Volume 5141, Diagnostic Optical Spectroscopy in Biomedicine II; (2003) https://doi.org/10.1117/12.500052
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

A new micro measuremen system - according to the principle of he EMPHO-System -has been developed to record tissue remission spectra within the range of 510 to 590nm. The device hardware basically involves a white LED,optical fibers,and a miniaturized grating spectrometer. In general,exact computation of blood oxygen saturation and relative hemoglobin concentration from these tissue remisson spectra is not possible. The main reason is that -except for oxyhemoglobin and desoxyhemoglobin -many other light-scattering and light-absorbing substances such as dopa-melanin and bilirubin cause measuremen errors. A new algorithm for the determination of local blood oxygen saturation and relative hemoglobin concentration from tissue remisson spectra is presented. This method is based on he probability of light photons propagation and reference coefficients. In addition, the algorithm also takes other light-scattering and light-absorbance substances in biological tissue into consideration. The method is compared with the standard procedure of Kubelka and Munk. Among others these two approaches are applied to the tissue remission spectra of ischaemia with subsequent reactive hyperemia. The calculated blood oxygen saturation and relative hemoglobin concentration of both methods are presented and discussed.

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Gerd Ehret, Ignaz Thiemann, and Eduard Reithmeier "Employing microtechnology for noninvasive determination of local blood oxygen saturation based on tissue remission spectra", Proc. SPIE 5141, Diagnostic Optical Spectroscopy in Biomedicine II, (8 October 2003); https://doi.org/10.1117/12.500052

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KEYWORDS

Tissues

Oxygen

Photons

Absorption

Tissue optics

Blood oxygen saturation

Signal attenuation

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