Intra- and extracerebral changes of hemoglobin concentrations by analysis of moments of distributions of times of flight of photons

Adam Liebert; Heidrun Wabnitz; Jens M. Steinbrink; Hellmuth Obrig; Michael Moeller; Rainer Macdonald; Herbert Rinneberg

doi:10.1117/12.500578

15 October 2003 Intra- and extracerebral changes of hemoglobin concentrations by analysis of moments of distributions of times of flight of photons

Adam Liebert, Heidrun Wabnitz, Jens M. Steinbrink, Hellmuth Obrig, Michael Moeller, Rainer Macdonald, Herbert Rinneberg

Author Affiliations +

Proceedings Volume 5138, Photon Migration and Diffuse-Light Imaging; (2003) https://doi.org/10.1117/12.500578
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

NIRS signals measured on the adult head contain contributions from the brain and from overlying tissue. It was shown recently that measured distributions of times of flight (DTOF) of photons allow to deduce absorption changes occurring in different layers of the head. This method relies on time-dependent mean partial pathlengths calculated by Monte Carlo simulations for assumed background optical properties of the various tissues. Deconvolution of the measured DTOF is required using the instrumental response function. We propose an alternative method to estimate absorption changes in various tissue layers by analyzing changes of moments of DTOFs (integral, mean time of flight and variance) recorded at various source-detector separations. The sensitivity factors corresponding to integral, mean time of flight and variance were obtained by Monte Carlo simulations for a layered model of the head. From experimentally derived mean time of flight and variance the contributions of the instrumental response function were subtracted. The proposed method was applied to multi-distance time-domain measurements during functional stimulation of the brain of healthy volunteers.

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Adam Liebert, Heidrun Wabnitz, Jens M. Steinbrink, Hellmuth Obrig, Michael Moeller, Rainer Macdonald, and Herbert Rinneberg "Intra- and extracerebral changes of hemoglobin concentrations by analysis of moments of distributions of times of flight of photons", Proc. SPIE 5138, Photon Migration and Diffuse-Light Imaging, (15 October 2003); https://doi.org/10.1117/12.500578

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