Development of a noninvasive corneal birefringence-compensated glucose-sensing polarimeter

Harini Anumula; Ajaina A. Nezhuvingal; Yanfang Li; Brent D. Cameron

doi:10.1117/12.477864

22 July 2003 Development of a noninvasive corneal birefringence-compensated glucose-sensing polarimeter

Harini Anumula, Ajaina A. Nezhuvingal, Yanfang Li, Brent D. Cameron

Proceedings Volume 4958, Advanced Biomedical and Clinical Diagnostic Systems; (2003) https://doi.org/10.1117/12.477864
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

In the recent past, optical polarimetry has been shown as a potential method for noninvasive physiologic glucose sensing in the eye. Although the necessary sensitivity and accuracy have been demonstrated experimentally through in vitro studies using a range of media from simplistic glucose doped-water to more complex media such as aqueous humor, the main problem currently hindering long-term in vivo measurements is corneal birefringence coupled with motion artifact. This is due to the inability to distinguish E-field rotation due to glucose from the effects of time varying corneal birefringence. In this investigation, the effect of corneal birefringence will be discussed and a potential method to overcome this problem will be presented with supporting results.

Citation Download Citation

Harini Anumula, Ajaina A. Nezhuvingal, Yanfang Li, and Brent D. Cameron "Development of a noninvasive corneal birefringence-compensated glucose-sensing polarimeter", Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); https://doi.org/10.1117/12.477864

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