High-temperature thermal treatment of the uterus

Thomas P. Ryan; Jia Hua Xiao; Juh Yun Chung

doi:10.1117/12.476629

10 June 2003 High-temperature thermal treatment of the uterus

Thomas P. Ryan, Jia Hua Xiao, Juh Yun Chung

Proceedings Volume 4954, Thermal Treatment of Tissue: Energy Delivery and Assessment II; (2003) https://doi.org/10.1117/12.476629
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

More than 200,000 hysterectomies are performed annually in the US due to abnormal uterine bleeding from excessive menstrual flow. A minimally invasive procedure has been developed using thermal treatment combined with pressure to the endometrial lining of the uterus. Results from a 3-D finite element model will be shown, as well as experimental data. Good correlation was seen between simulations and experiments. The study found similar results then temperatures were increased and times for treatment were shortened.More than 200,000 hysterectomies are performed annually in the US due to abnormal uterine bleeding from excessive menstrual flow. A minimally invasive procedure has been developed using a balloon-based thermal treatment combined with pressure to the endometrial lining of the uterus. A 3D finite element model was set up to simulate the balloon ablation device in the human uterus as used in over 150,000 patients to date. Several additional simulations were made at higher temperatures to seek alternative combinations with higher temperature and shorter time intervals for the same depth of penetration, or deeper penetration at longer times and elevated temperatures. A temperature range of 87 to 150°C was explored. The Bioheat Equation was used in the simulations to predict temperature distributions in tissue. The Damage Integral was also used to characterize the location at depth of irreversible damage in the uterus. Treatment safety issues were also analyzed as the simulations showed the depth of penetration into the myometrium, towards the serosa.

Citation Download Citation

Thomas P. Ryan, Jia Hua Xiao, and Juh Yun Chung "High-temperature thermal treatment of the uterus", Proc. SPIE 4954, Thermal Treatment of Tissue: Energy Delivery and Assessment II, (10 June 2003); https://doi.org/10.1117/12.476629

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