Effects of copper vapor laser (CVL) on mice skin: histologic evaluation of damage and tissue stimulation

Syllene Nunes; E. Moreno; H. Oliveira; J. Osaka; G. Salvador; N. Michalany; E. Tolosa

doi:10.1117/12.486603

15 October 2002 Effects of copper vapor laser (CVL) on mice skin: histologic evaluation of damage and tissue stimulation

Syllene Nunes, E. Moreno, H. Oliveira, J. Osaka, G. Salvador, N. Michalany, E. Tolosa

Author Affiliations +

Proceedings Volume 4903, Laser Florence 2001: A Window on the Laser Medicine World; (2002) https://doi.org/10.1117/12.486603
Event: Laser Florence 2001: a Window on the Laser Medicine World, 2001, Florence, Italy

Abstract

This study was to evaluate the effects of the CVL with low energy and short pulse widths. 18 female mice, C57BL/6 (9-11 weeks old) were distributed into four groups. The control group (CG) wasn't exposed to laser beam . Group L1 had 2 laser expositions with 24 hours gap between them (0.5W). Group L2 had 3 expositions (0.5W and 0.25W) and group L3 had 4 expositions (0.25 W). It was used a CVL prototype (5lOnm, 13 Khz, pulse width of 20 ms and spot size of 0.8cm). 7 days after last laser pulse no groups presented actinic keratosis, tumors or collagen changes. CVL had effective action on pilosebaceous units. High energy with few short pulses induced hair follicles proliferation while low energy with many repetitive short pulses showed increased and specific tissue damage besides hair plugging.

Citation Download Citation

Syllene Nunes, E. Moreno, H. Oliveira, J. Osaka, G. Salvador, N. Michalany, and E. Tolosa "Effects of copper vapor laser (CVL) on mice skin: histologic evaluation of damage and tissue stimulation", Proc. SPIE 4903, Laser Florence 2001: A Window on the Laser Medicine World, (15 October 2002); https://doi.org/10.1117/12.486603

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KEYWORDS

Skin

Laser tissue interaction

Collagen

Lithium

Tissues

Laser therapeutics

Cell death

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