Imaging fluorescence parameters by Bayesian optical diffusion tomography

Rick P. Millane; Adam M. Milstein; Quan Zhang; Seungseok Oh; Kevin J. Webb; Charles A. Bouman; David A. Boas

doi:10.1117/12.451799

23 December 2002 Imaging fluorescence parameters by Bayesian optical diffusion tomography

Rick P. Millane, Adam M. Milstein, Quan Zhang, Seungseok Oh, Kevin J. Webb, Charles A. Bouman, David A. Boas

Proceedings Volume 4792, Image Reconstruction from Incomplete Data II; (2002) https://doi.org/10.1117/12.451799
Event: International Symposium on Optical Science and Technology, 2002, Seattle, WA, United States

Abstract

A Bayesian optimization scheme is presented for reconstructing fluorescent yield and lifetime, the absorption coefficient, and the scattering coefficient in turbid media, such as biological tissue. The method utilizes measurements at both the excitation and emission wavelengths for reconstructing all unknown parameters. The effectiveness of the reconstruction algorithm is demonstrated by simulation and by application to experimental data from a tissue phantom containing a fluorescent agent.

Citation Download Citation

Rick P. Millane, Adam M. Milstein, Quan Zhang, Seungseok Oh, Kevin J. Webb, Charles A. Bouman, and David A. Boas "Imaging fluorescence parameters by Bayesian optical diffusion tomography", Proc. SPIE 4792, Image Reconstruction from Incomplete Data II, (23 December 2002); https://doi.org/10.1117/12.451799

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