Nonrigid mammogram registration using mutual information

Michael A. Wirth; Jay Narhan; Derek W. S. Gray

doi:10.1117/12.467198

9 May 2002 Nonrigid mammogram registration using mutual information

Michael A. Wirth, Jay Narhan, Derek W. S. Gray

Proceedings Volume 4684, Medical Imaging 2002: Image Processing; (2002) https://doi.org/10.1117/12.467198
Event: Medical Imaging 2002, 2002, San Diego, California, United States

Abstract

Of the papers dealing with the task of mammogram registration, the majority deal with the task by matching corresponding control-points derived from anatomical landmark points. One of the caveats encountered when using pure point-matching techniques is their reliance on accurately extracted anatomical features-points. This paper proposes an innovative approach to matching mammograms which combines the use of a similarity-measure and a point-based spatial transformation. Mutual information is a cost-function used to determine the degree of similarity between the two mammograms. An initial rigid registration is performed to remove global differences and bring the mammograms into approximate alignment. The mammograms are then subdivided into smaller regions and each of the corresponding subimages is matched independently using mutual information. The centroids of each of the matched subimages are then used as corresponding control-point pairs in association with the Thin-Plate Spline radial basis function. The resulting spatial transformation generates a nonrigid match of the mammograms. The technique is illustrated by matching mammograms from the MIAS mammogram database. An experimental comparison is made between mutual information incorporating purely rigid behavior, and that incorporating a more nonrigid behavior. The effectiveness of the registration process is evaluated using image differences.

Citation Download Citation

Michael A. Wirth, Jay Narhan, and Derek W. S. Gray "Nonrigid mammogram registration using mutual information", Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); https://doi.org/10.1117/12.467198

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