Probing brain cancer by fiber optic FTIR spectroscopy

Gerald Steiner; Angelique Kano; Tom Richter; Ralf Bergmann; Heike Rodig; Jens Kobelke; Bernd Johannsen; Reiner Salzer

doi:10.1117/12.463822

26 March 2002 Probing brain cancer by fiber optic FTIR spectroscopy

Gerald Steiner, Angelique Kano, Tom Richter, Ralf Bergmann, Heike Rodig, Jens Kobelke, Bernd Johannsen, Reiner Salzer

Proceedings Volume 4616, Optical Fibers and Sensors for Medical Applications II; (2002) https://doi.org/10.1117/12.463822
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

The use of several silver halide and chalcogenide infrared transmitting fibers in the detection of cancer is investigated. As a test sample for all types of fibers we used a thin section of an entire rat brain with glioblastoma. Moving the sample with an XY stage maps across the whole tissue section with more than 200 spectra were recorded. Data evaluation was performed using Principal Components Analysis (PCA). The silver halide fibers have provided excellent results. The tumor was clearly differentiable from the normal tissue. It wasn't possible to identify the tumor region using chalcogenide fibers because the fiber has a very low transmittance in the important fingerprint region.

Citation Download Citation

Gerald Steiner, Angelique Kano, Tom Richter, Ralf Bergmann, Heike Rodig, Jens Kobelke, Bernd Johannsen, and Reiner Salzer "Probing brain cancer by fiber optic FTIR spectroscopy", Proc. SPIE 4616, Optical Fibers and Sensors for Medical Applications II, (26 March 2002); https://doi.org/10.1117/12.463822

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