Near-infrared Raman spectroscopy for detection and classification of gastrointestinal disease

Nicholas Stone; Catherine A. Kendall; Nitya Chandratreya; Neil Shepherd; Hugh Barr M.D.

doi:10.1117/12.460788

27 March 2002 Near-infrared Raman spectroscopy for detection and classification of gastrointestinal disease

Nicholas Stone, Catherine A. Kendall, Nitya Chandratreya, Neil Shepherd, Hugh Barr M.D.

Proceedings Volume 4614, Biomedical Vibrational Spectroscopy II; (2002) https://doi.org/10.1117/12.460788
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

The prospect of utilising NIR-Raman spectroscopy for analysis of gastro-intestinal (GI) tissue has been explored both with snap-frozen and formalin fixed samples. In the oesophagus large sample numbers have been employed and the full spectrum of pathology has been studied. Multivariate analysis techniques have been employed to optimally separate the groups and spectral diagnostic models have been constructed and evaluated by employing cross-validation testing. Sensitivities have been shown to vary between 73 and 100 percent and specificities between 91 and 100 percent, depending on pathology group and tissue type.

Citation Download Citation

Nicholas Stone, Catherine A. Kendall, Nitya Chandratreya, Neil Shepherd, and Hugh Barr M.D. "Near-infrared Raman spectroscopy for detection and classification of gastrointestinal disease", Proc. SPIE 4614, Biomedical Vibrational Spectroscopy II, (27 March 2002); https://doi.org/10.1117/12.460788

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