Time-dependent spectra of PPIX after ALA and h-ALA application

Dirk Huettenberger; Hans-Jochen Foth; Volker Zenzen; Heinrich Zankl

doi:10.1117/12.469333

6 June 2002 Time-dependent spectra of PPIX after ALA and h-ALA application

Dirk Huettenberger, Hans-Jochen Foth, Volker Zenzen, Heinrich Zankl

Proceedings Volume 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI; (2002) https://doi.org/10.1117/12.469333
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

The transition of the tumor fluorescence from auto fluorescence towards PpIX fluorescence was studied under spectral and spatial resolution in an in-vivo tumour model. Human tumour cells were embedded on the chorioallantois membrane (CAM) of fertilised hen's eggs. A time period of 8 days is sufficient to grow tumours of a size of several millimeters. After the application of ALA and h-ALA the intensity and the wavelength spectra of the fluorescence were observed under blue light exposure (lambda) = 405 nm) by the spectrometer SpectraCube. 1-2 hours after the application of the photosensitizer the spectra show the yield of the typical double peak structure of PpIX.

Citation Download Citation

Dirk Huettenberger, Hans-Jochen Foth, Volker Zenzen, and Heinrich Zankl "Time-dependent spectra of PPIX after ALA and h-ALA application", Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); https://doi.org/10.1117/12.469333

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KEYWORDS

Content addressable memory

Luminescence

Tissues

Animal model studies

Spectroscopy

Tissue optics

Photodynamic therapy

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