Three-dimensional optical tomographic imaging of vascular reactivity in the brain

Andreas H. Hielscher; Avraham Bluestone; Gassan S. Abdoulaev; Joseph Lasker; Randall Locke Barbour; Christoph H. Schmitz

doi:10.1117/12.447424

2 November 2001 Three-dimensional optical tomographic imaging of vascular reactivity in the brain

Andreas H. Hielscher, Avraham Bluestone, Gassan S. Abdoulaev, Joseph Lasker, Randall Locke Barbour, Christoph H. Schmitz

Author Affiliations +

Proceedings Volume 4431, Photon Migration, Optical Coherence Tomography, and Microscopy; (2001) https://doi.org/10.1117/12.447424
Event: European Conferences on Biomedical Optics, 2001, Munich, Germany

Abstract

We report on the first three-dimensional, volumetric, tomographic localization of changes in the concentration of oxyhemoglobin and deoxyhemoglobin in the brain. To this end we have developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin and deoxyhemoglobin during a Valsalva maneuver are visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.

Citation Download Citation

Andreas H. Hielscher, Avraham Bluestone, Gassan S. Abdoulaev, Joseph Lasker, Randall Locke Barbour, and Christoph H. Schmitz "Three-dimensional optical tomographic imaging of vascular reactivity in the brain", Proc. SPIE 4431, Photon Migration, Optical Coherence Tomography, and Microscopy, (2 November 2001); https://doi.org/10.1117/12.447424

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available