Volume-pressure plots and viscoelasticity of finger arterioles in vivo by diode laser

Paolo Gizdulich; Francesco Mango

doi:10.1117/12.425167

9 April 2001 Volume-pressure plots and viscoelasticity of finger arterioles in vivo by diode laser

Paolo Gizdulich, Francesco Mango

Proceedings Volume 4397, 11th International School on Quantum Electronics: Laser Physics and Applications; (2001) https://doi.org/10.1117/12.425167
Event: 11th International School on Quantum Electronics: Laser Physics and Applications, 2000, Varna, Bulgaria

Abstract

Volume-pressure plots of human arteries can be revealed in vivo, in finger arterioles. To get such plots, we recorded the arterial blood pressure noninvasively by applying a standard method, and detected a signal proportional to the blood volume by using a diode laser. The interest comes from the utility of such topics for diagnostic purpose. One laser beam is focused on the soft portion of the middle phalanx of a finger. The laser beam penetrates the skin and is the blood volume. Such a volume pulses according to the blood pressure. At the finger a small cuff is applied and we control the transmural pressure by inflating and deflating the cuff. The laser operates through small holes in the cuff. The photodiode is inserted into the cuff. Despite of the arbitrary units obtained for the volumes (volume signal is not calibrated) the pattern of the function can be studied and analyzed. By simple mathematical elaboration, the 'relative' compliance of the system can be obtained. At the moment we got data from 5 subjects, and computed the pressure-volume curves and their parameters. The function obtained is highly nonlinear, and a phase shift between volume and pressure is documented as well as hysteresys effects. The study supports future developments of the method in order to calibrate the response and to get a plot of both the static and the dynamic Young modulus.

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Paolo Gizdulich and Francesco Mango "Volume-pressure plots and viscoelasticity of finger arterioles in vivo by diode laser", Proc. SPIE 4397, 11th International School on Quantum Electronics: Laser Physics and Applications, (9 April 2001); https://doi.org/10.1117/12.425167

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KEYWORDS

Blood

In vivo imaging

Blood pressure

Photodiodes

Semiconductor lasers

Signal detection

Calibration

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