Dynamics of fMRI signals during human brain activations to a stimulus

Haiying Liu; Toshinori Kato; Carlos Neves

doi:10.1117/12.428152

21 May 2001 Dynamics of fMRI signals during human brain activations to a stimulus

Haiying Liu, Toshinori Kato, Carlos Neves

Proceedings Volume 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images; (2001) https://doi.org/10.1117/12.428152
Event: Medical Imaging 2001, 2001, San Diego, CA, United States

Abstract

In fMRI memory study, the temporal behavior of BOLD fMRI signals were consistently observed from various brain processing areas at 1.5 Tesla and consistent with the expected functions. Also, all the activations generally exhibit three types of temporal characteristics: short, sustained and delayed responses in relation to the primary stimuli. To address these cerebral multiphasic responses, a suitable functional data analysis scheme has been used, in which the neural response of a specific brain area to a pre-determined stimulation input of some sort was assumed to be linear. The visual memory study was performed on 6 normal subjects on a clinical MR scanner using a 5 min long rapid dynamical whole brain imaging using EPI acquisition during a single memory task, which involved a 45 sec visual presentation of three simple abstract geometric figures to the subject via LCD projector. The results showed that the activations in visual cortex were tightly correlated with the visual stimulus, while the activations detected in interior temporal, entorhinal cortex and inferior temporal area were delayed. Using the new technique, the brian activations were further characterized quantitatively in terms of delay and prolonged response. The resulting effective impulse response functions corresponding to these brain activations revealed much clearly all the temporal components.

Citation Download Citation

Haiying Liu, Toshinori Kato, and Carlos Neves "Dynamics of fMRI signals during human brain activations to a stimulus", Proc. SPIE 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images, (21 May 2001); https://doi.org/10.1117/12.428152

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