Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy

John A. Viator; Guenther Paltauf; Steven L. Jacques; Scott A. Prahl

doi:10.1117/12.429311

15 June 2001 Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy

John A. Viator, Guenther Paltauf, Steven L. Jacques, Scott A. Prahl

Author Affiliations +

Proceedings Volume 4256, Biomedical Optoacoustics II; (2001) https://doi.org/10.1117/12.429311
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

An endoscopic photoacoustic probe is designed and tested for use in PDT treatment of esophageal cancer. The probe, measuring less than 2.5 mm in diameter, was designed to fit within the lumen of an endoscope that will be inserted into an esophagus after PDT. PDT treatment results in a blanched, necrotic layer of cancerous tissue over a healthy, deeper layer of perfused tissue. The photoacoustic probe was designed to use acoustic propagation time to determine the thickness of the blanched surface of the esophagus, which corresponds to treatment depth. A side-firing 600 micrometers fiber delivered 532 nm laser light to induce acoustic waves in the perfused layer of the esophagus beneath the blanched (treated) layer. A PVDF transducer detected the induced acoustic waves and transmitted the signal to an oscilloscope. The probe was tested on clear and turbid tissue phantom layers over an optically absorbing dye solution.

Citation Download Citation

John A. Viator, Guenther Paltauf, Steven L. Jacques, and Scott A. Prahl "Design and testing of an endoscopic photoacoustic probe for determination of treatment depth after photodynamic therapy", Proc. SPIE 4256, Biomedical Optoacoustics II, (15 June 2001); https://doi.org/10.1117/12.429311

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